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Medulloblastoma - Aetiology
- Unknown for most patients
- Familial cases
•
SIR 4.1 for siblings
- Genetic susceptibility
Genetic susceptibility
-Seen in several familiar cancer predisposition
syndromes (Gorlin syndrome, Turcot syndrome,
Li-Fraumeni syndrome, Fragile X syndrome,….)
-Frequency 10% overall, 30% of pts < 3 years
-Genetic counselling/screening of family members