1426-1427 / 2437
Medulloblastoma
History of Chemotherapy Clinical Trials:
1970s-1980s:
-Adjuvant chemotherapy
-SIOP I,CCSG 942
1980s-1990s:
-Pre-RT (Sandwich CT)
-SIOP II, SIOP/UKCCSG PNET 3
-Pre vs post RT chemotherapy : HIT 91,CCG 921
-CCG 9862 adjuvant chemotherapy (CVP)
Chemo better for high-risk subgroups
Standard dose RT (35-36 Gy
established)
Intensive sandwich CT better than RT
alone (PNET 3)
Immediate RT better than delayed
Cisplatin,
VCR,CCNU
chemo standard and
reduced dose RT (23.4
Gy) established