![Show Menu](styles/mobile-menu.png)
![Page Background](./../common/page-substrates/page0793.png)
Stratum 3: NF-1 associated
Low Grade Glioma
• N=25 eligible and evaluable
– Expansion beyond first 16 was justified on imaging based on statistical design
– Only 3 with tissue and all negative for both BRAF alterations tested
• Best response (regardless of timeframe):
– 10 PR, 14 SD, only 1 PD during treatment
– 18 patients completed all 26 courses
– 4 patients progressed while off treatment
• 3 completed 26 course and 1 completed 24 courses (came off due to toxicity)
• All patient completed therapy