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1. Carbamazepine CBZ
2. Gabapentin
GBP
3. Lacosamide
LAC
4. Lamotrigine
LTG
5. Levetiracetam LEV
6. Oxcarbazepine
OXC
7. Perampanel
PER
8. Phenobarbital
Pb
9. Primidon
PRM
10. Phenytoin
PHT
11. Pregabalin
PGB
12. Topiramate
TPM
13. Valproic acid
VPA
14. Zonisamide
ZON
„time to treatment failure“:
LTG > CBZ, GBP und TPM
Time from randomization (years)
„seizure control“
LEV = CBZ
Brodie et al., Neurology 2007
Marson et al., Lancet 2007
How to choose the best AED