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Phenobarbital
Sedation, allergic reactions
Enzyme induction
(cytochrome P450)
Phenytoin
Vertigo, allergic reactions, liver enzymes
,
gingival hyperplasia, cerebellar degeneration
Enzyme induction
(cytochrome P450)
Carbamazepine
Vertigo, Nausea, Ataxia, low blood sodium,
nystagmus, allergic reactions,
Enzyme induction
(cytochrome P450)
Valproic acid
Tremor, gain of weight, coagulation disorders,
thrombopenia, teratogenicity
Enzyme inhibition
Old AED: pros and cons