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Risk of Neurocognitive impairment after RT
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The risk in patients treated for glioma is mainly related to
large volume (no WB better) (1)
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The risk of dementia in long survivors after WBRT in
patients treated for brain metastases is strongly related to
fractionation (<3Gy better)
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Rate of Neurocog sequelae is lower than 3% for partial
brain irradiation, while respecting dose constraints
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Experiences on normal NSCs department avoidance also
with larger treatment volumes are promising (3)
(1) Sarkissian et al. Neurol Lett, 2005
(2) De Angelis et al. Neurology, 1989
(3) Barani et al. IJROBP, 2007