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Studies on neuro-toxicity in gliomas
Author year
Setting Tumor Nr
Dose Resp.
Tumor
PD
Taylor
1998
Pro
HGG
701
60Gy
No significant
Neurotoxicity
Worsening of
NC
Brown
2001
Pro
LGG
203
50.4 vs 64
Gy
Worsening at 1,
2, 5 years: 8.2,
4.6, 5.3%
Significant
improvement
59%, 50%,
and 67% at
years 1, 2,
and 5,
Armstrong
2000
Pro
LGG
20
46-63 Gy Verbal decline at
3m, recovery at
1y
-
Vigliani
1996
Pro
LGG
17
54-55.8
Gy
No tox
compared to
matched pairs,
improvement*
-
Klein
2001
Retro
LGG
195
n.r.
No significant
impairment
n.r.
Taphoorn
1994
Retro
LGG
41
(20 RT/21 Sg
only)
45-63 Gy No difference
Comparison to
19 haem dis.
CHT,LGG both
groups with
lower
Cog/mood/asteni
a
-