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Neural Stem Cells and RT toxicity
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NSCs exhibit exquisite in situ
radiosensitivity
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Radiation can directly depopulate NSC
niches, causing immediate loss of NSC-
mediated repair and plasticity
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Indirect effects of radiation are
inflammatory in nature, dose dependent,
and capable of stunting neurogenesis
even at low doses
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The scope of NSC dysfunction is age
dependent, with greater effects noted in
immature brains
Barani I, IJROBP 2007