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REIRRADI ATION TOLERANCE OF THE HUMAN BRAIN
R
AMONA
M
AYER
, M.D., M.S
C
.,
*
AND
P
ETER
S
MINIA
, P
H
.D.
y
* Department of Therapeutic Radiology and Oncology, Medical University of Graz, Graz, Austria; and
y
Department of Radiation
Oncology, Division Radiobiology, VU University Medical Center, Amsterdam, The Netherlands
•
Radiation-induced normal brain tissue necrosis was
found to occur at NTD
cumulative
>
100 Gy
•
The applied reirradiation dose and NTD
cumulative
were
found to increase with a change in irradiation technique
from conventional to conformal techniques such as FSRT
to SRS, without increasing the probability of normal brain
necrosis.
•
The analysis shows the applied
total cumulative dose
to
be the most important factor with regard to the
development of
radionecrosis
•
Reirradiation is a feasible option as palliative therapy for
recurrent high grade glioma
R Mayer, et al., IJROBP, 2008