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Chemotherapy and the BBB
Drug
CSF penetration
Nitrosoureas
(ACNU,BCNU; CCNU, Fotemustine)
++
Procarbazine
++
Thiotepa
+
Dacarbazine
Temozolomide
(+)
++
Cyclophosphamide, Ifosfamide
+/-
AraC
++
Methotrexate
-/+
5-FU
(++)
Anthracyclins
Liposomal doxorubicine
-
++
VM26
-/+
Etoposide
-/+
Vincaalkaloids, Taxanes
-
Topotecan
++
Cisplatin, Carboplatin
-
Müller et al., Malignant brain tumors 1995