722-723 / 2437
Temozolomide
03/01/13
• Imidazotetrazine derivative of dacarbazine
• Conversion in the systemic circulation at physiological pH to the active
compound, 3-methyl-(triazen-1-yl)imidazole-4-carboxamide (MTIC)
• Good BBB penetration
• Oral application (note: there is also an i.v. formulation)
• Methylation of O6 guanine:
Tumor cell death