9 / 2437
07.11.2017
9
49
4. Which molecular markers do you routinely test for
neuropathological work-up of diffuse gliomas?
0 25 50 75 100
IDH1
IDH2
1p 19q
MGMT
ATRX
TERT
Other
Yes No
%
Woehreretal,ClinNeuropathol2017
50
4. Which molecular markers do you routinely test for
neuropathological work-up of diffuse gliomas?
Eu Af
SA
As NA Au
High Low
Yes Sometimes
No
Yes No
High Low Income
Yes No
*GrossDomestic Product
64 %
Limited access
§
§
§
§
§
Woehreretal,ClinNeuropathol2017
51
4. Which molecular markers do you routinely test for
neuropathological work-up of diffuse gliomas?
High within-country heterogeneity
Yes No
High Low
Yes Sometimes
No
High Low Income
10+ responses
Woehreretal,ClinNeuropathol2017
52
5. Which molecular techniques and platforms do you
currently use?
Gene panel sequencing
Targeted gene sequencing
Methylation-specificPCR
Pyrosequencing
Fluorescence in situhybridization
Multiplex lig.-depend. probe amplification
Methylation array
Yes No
0 25 50 75 100
%
Woehreretal,ClinNeuropathol2017
53
5. Which molecular techniques and platforms do you
currently use?
Yes No
Yes No
Eu Af
SA
As NA Au
High Low
Yes Sometimes
No
High Low Income
> 50 %
No access
§
Variable
combinations
§
≈ Mutually
exclusive
Woehreretal,ClinNeuropathol2017
54
5. Which molecular techniques and platforms do you
currently use?
High Low
Yes Sometimes
No
Yes No
High Low Income
High within-country heterogeneity
(might indicate centralization of diagnostic
services)
Woehreretal,ClinNeuropathol2017