932-933 / 2437
What is PCV?
Procarbazine
Lomustine (CCNU)
Vincristine
p.o.
p.o.
i.v.
Alkylating agent
Breaking of DNA strands
Alkylating nitrosourea
compound
Breaking of DNA strands
Vinca alkoid
Mitotic inhibitor –
inhibiting the assembly
of microtubule structures
Good penetration trough
blood-brain-barrier
Good penetration trough
blood-brain-barrier
Moderate to low penetration
trough blood-brain-barrier
Molecular weight: 258 Da
Molecular weight: 233 Da
Molecular weight: 923 Da
Dose limiting side effects:
Hematotoxicity
High (>90%) emetogenic
Dose limiting side effects:
Hematotoxicity
Dose limiting side effects:
Peripheral neuropathy