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Radiogenomics: the biological basis of the

radiomics-heterogeneity signature

Radiomics

Dataset of 88 Stage I NSCLC patients treated with surgery

Tumors delineated with a validated software

440 radiomics features were extracted from these segmented tumor regions

Gene-expression profiling for each patient (22.000 genes measured)

Genomics

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Radiomic-Genomics

Aerts…Lambin, Nature Commun 2014