Quantitative Methods 2017

Indication protocol

Head and neck cancer

Endpoint

Source ∆NTCP Level of

evidence

Moderate-to severe

xerostomia (patient-rated

EORTC QLQ-HN35)

Beetz 2012 ≥ 10% Level 3

Dysphagia grade ≥ II (CTCAE)

Christianen

2012

≥ 10% Level 3

Tube feeding dependence

Wopken 2014 ≥ 5% Level 3

External validation in new dataset from UMCG.

Analysis performed by independent party: The Health Innovation

Center (THINC)