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Taking clinical risk factors into account
•
One way is to introduce a dose modifying factor:
•
Where
d
i
are fitting parameters and Y
i
are (typically)
indicator variables of presence/absence of a risk
factor.
•
If exp(
d
i
Y
i
)<1: Risk factor or protective factor?
....
exp
exp
22
11
50
50
Y
Y
D D
eff
d
d