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Example

Risk of grade 3+ Radiation pneumonitis

D

50

=54.1 Gy for smokers

exp(

d

i

Y

i

)=0.79 (95% CI: 0.4-0.98) for former smokers

exp(

d

i

Y

i

)=0.65 (95% CI: 0.27-0.89) for non-smokers

Is smoking protective or risk factor?

From: Tucker et al, IJROBP

72

p. 568 (2008)