Quantitative Methods 2017

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High risk (low control)

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Accrual outside hospital / department

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Many doctors including patients

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Prognostic factor studies with high patient burden:

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e.g. baseline and repeated follow up imaging

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Low risk (keep in control):

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Accrual inside department (screening in advance)

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Research nurse or physician (accrual and logistics)

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Less burden for treating physicians

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Keep study design simple and not to burdensome for

patients

Prospective data registration

Threats for low accrual / low compliance