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The Price of Target Homogeneity
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Previous ICRU reports recommended that the dose values in the
PTV be confined within 95% and 107% of the prescribed dose.
•
With IMRT, these constraints may be confining if the avoidance of
OARs is more important than target dose homogeneity
“No data have demonstrated that uniform doses are
radiobiologically preferable in general”
Craft et al., 2016 IJROBP