Muscle relaxants 783
• Obtain liver function test results at begin
ning of therapy.
• Prepare oral suspension for single dose by
dissolving capsule contents in juice or other
liquid. For multiple doses, use acid vehicle
and refrigerate. Use within several days.
• Watch for hepatitis (fever and jaundice),
severe diarrhoea, severe weakness or sensit
ivity reactions (fever and skin eruptions).
Withhold dose and notify prescriber if these
occur.
• Amount of relief in individual determines
whether dosage (and drowsiness) can be
reduced.
Patient teaching
• Instruct person to take drugwithmeals or
milk in four divided doses.
• Advise person to use cautionwhen eating
to avoid choking. Some individuals may
experience difficulty swallowing during
therapy.
• Warn person to avoid driving and other
hazardous activities until CNS effects of
drug are known.
• Advise person to avoid combining drug
with alcohol and other CNS depressants.
• Instruct person to avoid photosensitivity
reaction by using sunblock and wearing
protective clothing, to report abdominal
discomfort or GI problems immediately and
to follow prescriber’s orders regarding rest
and physical therapy.
mebeverine hydrochloride
Colese, Colofac
Pregnancy risk category B2
Use in sport: Permitted
Available form
Tablets:
135 mg
Indications & dosages
➤
Managementofirritablebowelsyndrome—
Adults:
135 mg PO t.i.d.
Action
Antimuscarinic. Antispasmodic and smooth
muscle relaxant.
Route Onset
Peak Duration
PO Unknown 13 hrs 24 hrs
Adverse reactions
CNS:
dizziness, headache, insomnia,
malaise.
CV:
bradycardia.
GI:
nausea, constipation, dyspepsia,
heartburn.
Metabolic:
anorexia.
Skin:
facial oedema, urticaria.
Other:
angio-oedema
,
anaphylaxis
, hyper-
sensitivity reaction.
Interactions
None reported.
Contraindications
Contraindicated in individuals with hyper
sensitivity to the drug or other components
of the preparation and in those with severe
hepatic impairment.
care considerations
• Use cautiously in individuals with cardiac
arrhythmia, heart block, angina, ischaemic
heart disease or liver or renal impairment.
• Liver function tests should be performed
regularly in individualswith liver impairment.
• Preparation contains lactose and sucrose
so caution is required in individuals with
potential intolerance or relevantmalabsorp
tion syndrome.
• Not recommended in the first trimester of
pregnancy.
Patient teaching
• Advise person to take drug at the same
time each day, 20 minutes before meals.
• Warn person to avoid driving and other
hazardous activities until CNS effects of
drug are known.
• Instruct person to continue taking the
medication, even if feeling well.
