1314 Miscellaneous drug categories
Reactions may be
common
, uncommon,
life-threatening
, or
commonandlife-threatening.
• Store reconstituted solution at 2–8
°
C and
use within 12 hours of preparation.
• Individuals should be requested to fast
overnight or to have only a light breakfast
on the morning of the procedure.
• Monitor vital signs and renal function
closely following procedure.
• Ensure safety if the person is light-headed.
Patient teaching
• Encourage person to void after the pro
cedure and regularly thereafter.
• Advise person to drink fluids regularly.
• Advise person to report any adverse
effects.
• Advise person to take care when standing
up or getting out of bed due to potential
dizziness.
• Instruct women who are breastfeeding
to discontinue breastfeeding for at least
24 hours and substitute with formula or
expressedbreastmilkpriortotheprocedure.
thyrotrophin alfa
Thyrogen
Pregnancy risk category B2
Use in sport: Permitted
Available form
Powder for injection:
1.1 mg
Indications & dosages
➤
Serumthyroglobulin(Tg)testingfordetection
of thyroid remnants post-thyroidectomy,
therapeuticuseinindividualspost-thyroidectomy
maintainedonhormonesuppressiontherapyin
combinationwithradioactive iodine—
Adults:
0.9 mg IM followed by second
0.9 mg IM 24 hours later.
IV ADMINISTRATION:
Reconstitute 1 vial with 1.2 mL of Sterile
Water for Injection. After reconstitution,
the thyrotrophin alfa concentration is
0.9 mg/mL.
Action
Purified recombinant form of human
thyroid-stimulating hormone (TSH).
Route Onset
Peak
Duration
IM Immediate 5 mins–4 hrs 48 hrs
Adverse reactions
CNS:
cerebrovascular accident
, dizziness,
fatigue, headache, hemiparesis, hemiplegia,
hypaesthesia, paraesthesia.
CV:
myocardialinfarction
,
atrialarrhythmia
.
ENT:
laryngeal oedema
.
Eye:
loss of vision.
GI:
diarrhoea, loss of taste,
nausea
, vomiting.
Metabolic:
hypercholesterolaemia, hyper
thyrodism, hypothyroidism, hyepertriglycer
idaemia, raised serum uric level.
Musculoskeletal:
arthralgia, myalgia, asth
enia.
Psychiatric:
anxiety, insomnia, mood dis
turbance.
Respiratory:
dyspnoea,
respiratory dis
tress
,
stridor
.
Skin:
flushing, pruritus, rash, sweating,
urticaria.
Other:
anaphylaxis
, asthenia, chills, fever,
flu-like syndrome, hypersensitivity reaction,
malaise.
Interactions
None reported.
Contraindications
None reported.
care considerations
• Monitor thyroid function.
• Monitor vital signs following procedure.
• Ensure safety if the person is light-headed.
Patient teaching
• Advise person to report any adverse
effects.
• Advise person to take care when standing
up or getting out of bed due to potential
dizziness.
