Diagnostic preparations 1305
• Observe for signs of lactic acidosis.
• Ensure safety if the person is light-headed.
• Thyroid function testsmay be reduced for
up to several weeks.
• False positive result for protein in the urine
maybereturnedonmultistixmeasurements
of specific gravity.
Patient teaching
• Advise person to report any adverse
effects.
• Advise person to take care when standing
up or getting out of bed due to potential
dizziness.
iohexol
Omnipaque
Pregnancy risk category NR
Use in sport: Permitted
Available forms
Solution for injection (intrathecal):
180 mg
iodine/mL in 15 mL
Solution for injection (intravascular, oral and
bodycavities):
388mg/mL in 15mL; 518mg/
mL in 50 mL; 647 mg/mL in 20 mL, 50 mL,
75mL, 100mL; 755mg/mL in 20mL, 50mL,
75 mL, 100 mL, 200 mL
Indications & dosages
➤
X-rayorCTcontrastmedium—
Adults:
Individualised according to
individual factors and nature of X-ray or
CT scan.
Action
Water-solubleradiographiccontrastmedium.
Route Onset
Peak
Duration
IV
Immediate Unknown 24 hrs
Adverse reactions
CNS:
altered consciousness,
convulsions
,
dizziness, dysgeusia, headache, motor
dysfunction, pain, sensory disturbance.
CV:
arrhythmia, bradycardia, flushing,
hypertension, hypotension, ischaemia,
myocardial ischaemia
,
thrombosis
,
thrombophlebitis
,
ventricularhypokinesia
.
Endocrine:
pancreatitis (in body cavities),
thyrotoxicosis
.
Eye:
transient blindness.
GI:
abdominal pain, diarrhoea, enlarged
salivary glands, nausea, vomiting.
GU:
renalfailure
,
contrastmedium–induced
nephrotoxicity
.
Haematological:
elevated serum amylase
(in body cavities).
Musculoskeletal:
arthralgia, arthritis.
Psychiatric:
confusion.
Respiratory:
bronchospasm
, cough, dys
pnoea, pulmonary oedema.
Skin:
erythema, pruritus, rash, urticaria.
Other:
anaphylactic reaction
, fever, hyper
sensitivityreactions, iodism,malaise,pyrexia.
Interactions
Drug-drug.
Metformin/biguanides:
Potent
ial transient impairment of renal function
with possible lactic acidosis. Monitor
closely.
Interleukin-2:
Increased risk of delayed
reactions. Monitor closely.
Beta blockers:
Atypical anaphylaxis. Monitor
closely.
Contraindications
Contraindicated in individuals with known
hypersensitivity to the preparation or a
history of serious hypersensitivity to iohexol;
and in those with thyrotoxicosis, anuria or
decompensated cardiac insufficiency. Also
contraindicated in carotid angiography,
during the progressive period of stroke, in
coronary arteriography in the first 4 weeks
after MI and in the presence of infection
or open injury in or near the region to be
examined.
care considerations
• Closelymonitor individualfordevelopment
of anaphylactic reaction. Ensure emergency
management equipment is available and in
correct working order.
• Monitor vital signs and renal function
closely following procedure.
