Diagnostic preparations 1301
CV:
arrhythmias, bradycardia,
cardiac
arrest
, flushing, hypertension, hypotension,
shock
, tachycardia, thrombophlebitis,
vasodilation.
ENT:
altered hearing, ear pain.
Eye:
eyepain, lacrimation,visualdisturbance.
GI:
abdominal pain, diarrhoea, dry mouth,
nausea, oral soft-tissue pain, toothache,
vomiting.
GU:
acute kidney injury
.
Hepatic:
elevated serumbilirubin, elevated
liver enzymes.
Metabolic:
thirst.
Musculoskeletal:
arthralgia, back pain,
nephrogenic systemic fibrosis
, pain in
extremity.
Psychiatric:
agitation, confusion, disorien
tation.
Respiratory:
bronchospasm
, cough, dys
pnoea,pharyngolaryngealpain,
respiratory
arrest
,
respiratory distress
.
Other:
anaphylactic reaction
,
angio-
oedema
, asthenia, fatigue, hypersensitivity,
injection site pain, malaise.
Interactions
None reported.
Contraindications
Contraindicated in individuals with known
hypersensitivity to the preparation; in
those with acute or chronic severe renal
insufficiency or renal insufficiency due
to hepatorenal syndrome; and in the
perioperative period in liver transplantation.
care considerations
• Increased risk of nephrogenic systemic
fibrosis in individuals with acute or chronic
renal failure or acute renal insufficiency,
or during the perioperative period in liver
transplantation. Renal function should
be assessed in all individuals prior to the
procedure.
• Closelymonitorindividualfordevelopment
of anaphylactic reaction. Ensure emergency
management equipment is available and in
correct working order.
• Monitor vital signs closely following
procedure.
Patient teaching
• Advise person to report any adverse
effects.
gadoteric acid
Dotarem
Pregnancy risk category B2
Use in sport: Permitted
Available forms
Vial:
279.32mg/mL (0.5mmol/mL) in 10mL
Prefilled syringe:
279.32 mg/mL in 10 mL
Indications & dosages
➤
EnhancementofCNSorwhole-bodyMRI—
Adultsandchildrenover2years:
0.1mmol/
kgbodyweight(0.2mL/kgbodyweight)by IV
bolus or infusion.
Action
Paramagnetic contrast agent used for imag
ing of intracranial and spinal lesions in
presence of abnormal blood–brain barrier
or abnormal vascularity, as well as whole-
body imaging.
Route Onset
Peak
Duration
IV
Immediate Unknown 24 hrs
Adverse reactions
CNS:
dizziness, generalised convulsions,
headache, paraesthesia, tremor, warm
sensation, somnolence.
CV:
arrhythmias, bradycardia,
cardiac
arrest
,
circulatory collapse
, flushing, hypo
tension, palpitations,
shock
, tachycardia.
ENT:
cochleovestibular disorder.
Eye:
conjunctivitis, eyelid oedema, eye pain,
lacrimation, visual disturbance.
GI:
abdominal pain, diarrhoea, excessive
salivation, nausea, vomiting.
GU:
acute kidney injury
.
