1302 Miscellaneous drug categories
Reactions may be
common
, uncommon,
life-threatening
, or
commonandlife-threatening.
Musculoskeletal:
arthralgia, back pain,
nephrogenic systemic fibrosis
, pain in
extremity.
Psychiatric:
agitation, confusion, disorien
tation.
Respiratory:
bronchospasm
, cough, dry
throat, dyspnoea,
laryngospasm
, nasal
congestion, pharyngolaryngeal pain,
respiratory arrest
,
respiratory distress
,
sneezing.
Skin:
eczema, erythema, pruritus, rash,
urticaria.
Other:
anaphylactic reaction
,
angio-
oedema
, asthenia, fatigue, hypersensitivity,
injection site pain, malaise.
Interactions
None reported.
Contraindications
Contraindicated in individuals with known
hypersensitivity to the preparation and in
those with pacemakers or vascular clips.
care considerations
• Increased risk of nephrogenic systemic
fibrosis in individuals with acute or chronic
renal failure or acute renal insufficiency,
or during the perioperative period in liver
transplantation. Renal function should
be assessed in all individuals prior to the
procedure.
• Closelymonitor individualfordevelopment
of anaphylactic reaction. Ensure emergency
management equipment is available and in
correct working order.
• Monitor vital signs closely following
procedure.
Patient teaching
• Advise person to report any adverse
effects.
gadoteridol
ProHance
Pregnancy risk category B3
Use in sport: Permitted
Available forms
Vial:
279.3 mg/mL in 15 mL, 20 mL
Prefilledsyringe:
279.3mg/mL in10mL,15mL
Indications & dosages
➤
EnhancementofCNSorwhole-bodyMRI—
Adultsandchildrenover2years:
0.1mmol/
kg bodyweight by IV bolus or infusion.
Action
Paramagnetic contrast agent used for
imaging of intracranial and spinal lesions in
presence of abnormal blood–brain barrier or
abnormal vascularity, as well as whole-body
imaging.
Route Onset
Peak
Duration
IV
Immediate Unknown 24 hrs
Adverse reactions
CNS:
burning sensation, cold sensation,
coma
,
convulsions
, dizziness, headache,
seizure, syncope, warm sensation.
CV:
angina pectoris, arrhythmias, brady
cardia,
cardiac arrest
,
circulatory collapse
,
cyanosis, hypertension, hypotension, palpi
tations, syncope, tachycardia, vasodilation.
ENT:
deafness.
Eye:
altered lacrimation, conjunctivitis, eye
disorder.
GI:
abdominal pain, diarrhoea, dysphagia,
gingival swelling, mouth oedema, nausea,
taste alteration, tongue oedema, vomiting.
GU:
acute kidney injury
, urinary incontin
ence.
Musculoskeletal:
arthralgia, back pain,
chest pain,
nephrogenic systemic fibrosis
,
pain in extremity.
Psychiatric:
agitation, confusion, disorien
tation.
