1312 Miscellaneous drug categories
Reactions may be
common
, uncommon,
life-threatening
, or
commonandlife-threatening.
Beta blockers:
Atypical anaphylaxis. Monitor
closely.
Neuroleptics and phenothiazine derivative
antidepressants:
Reduce seizure threshold.
Should be discontinued 48 hours prior to
and not resumed for 24 hours following
procedure.
Pethidine:
Potential spasms of sphincter of
Oddi. Monitor closely.
Contraindications
Contraindicated in individuals with known
hypersensitivity to the preparation or
a history of serious hypersensitivity to
iodine-containing contrast media; in those
with severe cardiovascular insufficiency,
thyrotoxicosis, anuria, severe functional
disorder of liver or kidneys or monoclonal
IgM gammopathy; in children under 14
years old; and in women who are pregnant.
care considerations
• Closelymonitor individualfordevelopment
of anaphylactic reaction. Ensure emergency
management equipment is available and in
correct working order.
• Monitor vital signs and renal function
closely following procedure.
• Ensure the person is well-hydrated before
and after the procedure to avoid contrast-
induced nephropathy.
• Assess mental status.
• Ensure safety if the person is light-headed.
• Thyroid function testsmay be reduced for
up to several weeks.
Patient teaching
• Advise person to report any adverse
effects.
• Advise person to take care when standing
up or getting out of bed due to potential
dizziness.
• Caution person that delayed effects may
impact on safety when driving or operating
machinery.
metyrapone
Metopirone
Pregnancy risk category B2
Use in sport: Permitted
Available form
Capsules:
250 mg
Indications & dosages
➤
Diagnosis of latent ACTH deficiency,
assessment of degree of ACTH suppression
duringorafterglucocorticoidtherapy,differential
diagnosis of adrenocortical hyperfunction in
Cushing’ssyndrome—
Single-dose test: Adults and children:
30 mg/kg (maximum dose 3 g) PO with
yoghurt or milk around midnight prior to
test.The blood sample for the assay is taken
early the followingmorning (7.30–8.00 am).
Multiple-dose test: Adults:
500–750 mg
PO q 4 hours for six doses to maximum
3–4.5 g.
Children:
15 mg/kg (minimum dose 250
mg) PO q 4 hours for six doses. Urinary
steroid levels are measured for 24 hours
before and within 24 hours following the
test.
Action
Reverses biosynthesis of cortisol, cortico
sterone and aldosterone in adrenal cortex.
Route Onset
Peak
Duration
PO
2 hrs
24 hrs
24 hrs
Adverse reactions
CNS:
dizziness,headache, light-headedness,
sedation.
CV:
hypertension.
Endocrine:
adrenal insufficiency.
GI:
abdominal pain, nausea, vomiting.
Haematological:
bone marrow failure
.
Skin:
allergic reaction, alopecia, hirsutism,
rash.
