Diagnostic preparations 1307
and in investigations of the female genitalia
in suspected or confirmed pregnancy.
care considerations
• Closelymonitorindividualfordevelopment
of anaphylactic reaction. Ensure emergency
management equipment is available and in
correct working order.
• Monitor vital signs and renal function
closely following procedure.
• Ensure the person is well-hydrated before
and after the procedure to avoid contrast-
induced nephropathy.
• Assess mental status.
• Ensure safety if the person is light-headed.
• Thyroid function testsmay be reduced for
up to several weeks.
Patient teaching
• Advise person to report any adverse
effects.
• Advise person to take care when standing
up or getting out of bed due to potential
dizziness.
iopamidol
Isovue
Pregnancy risk category B3
Use in sport: Permitted
Available forms
Solution for injection:
200 mg iodine/mL
in 10 mL, 20 mL, 50 mL; 300 mg iodine/
mL in 10 mL, 20 mL, 50 mL, 70 mL, 100 mL;
370 mg iodine/mL in 20 mL, 30 mL, 50 mL,
70 mL, 100 mL, 150 mL, 200 mL
Indications & dosages
➤
X-rayorCTcontrastmedium—
Adults:
Individualised according to
individual factors and nature of X-ray or
CT scan.
Action
Non-ionic iodinated radiographic contrast
medium for vascular systems.
Route Onset
Peak
Duration
IV
Immediate Unknown 96 hrs
Adverse reactions
CNS:
abnormal coordination,
convulsions
,
dizziness,drymouth,EEGchanges,headache,
hypaesthesia, meningismus, meningitis,
nervousness, neuropathy, paraplegia,
paraesthesia, somnolence, syncope.
CV:
anginapectoris,arrhythmia,bradycardia,
cardiac arrest
,
circulatory collapse
,
dis
seminated intravascular coagulation
,
ECG changes, hypertension, hypotension,
myocardial ischaemia
, palpitations,
thrombophlebitis, ventricular and supra
ventricular ectopic beats,
ventricular
fibrillation
.
ENT:
nasal congestion, rhinitis, sneezing.
Eye:
altered vision, blindness, conjunctivitis,
eye disorder, itchiness, mydriasis, oculogyric
crisis, periorbital oedema. photophobia.
GI:
abdominal pain, anorexia, diarrhoea,
dysphagia, nausea, rectal haemorrhage,
vomiting.
GU:
acuterenalfailure
,alteredrenalfunction
contrast medium–induced nephrotoxicity
,
incontinence, urinary retention.
Musculoskeletal:
asthenia, muscle cramps,
myalgia, myopathy.
Psychiatric:
agitation, amnesia, confusion.
Respiratory:
asthma,
bronchospasm
,
dyspnoea,
laryngeal oedema
, pharyngitis,
pulmonary oedema, respiratory distress.
Skin:
angio-oedema
,clamminess,erythema,
flushing, injection site pain, itching, pruritus,
rash, sweating, urticaria.
Other:
anaphylactic reaction, fever, hyper
sensitivityreactions, iodism,malaise,pyrexia,
rigors.
Interactions
Drug-drug.
Metformin/biguanides:
Potential
transient impairment of renal function
with possible lactic acidosis. Should be
discontinued 48 hours prior to and for 48
hours after procedure.
Interleukin-2:
Increased risk of delayed
reactions. Monitor closely.
