1300 Miscellaneous drug categories
Reactions may be
common
, uncommon,
life-threatening
, or
commonandlife-threatening.
Action
Paramagnetic contrast agent used for
imaging of intracranial and spinal lesions in
presence of abnormal blood–brain barrier or
abnormal vascularity.
Route Onset
Peak
Duration
IV
Immediate Unknown 24 hrs
Adverse reactions
CNS:
ataxia, light-headedness, somnolence,
tremor.
CV:
angina pectoris, arrhythmias,
cardiac
arrest
,
circulatory failure
, hypertension,
hypotension, tachycardia, vasodilation.
ENT:
tinnitus.
Eye:
visual disturbance.
GI:
abdominal pain, diarrhoea, dry mouth,
faecal incontinence, nausea, taste alteration.
GU:
acute kidney injury
, urinary incontin
ence.
Musculoskeletal:
myalgia,
nephrogenic
systemic fibrosis
.
Psychiatric:
anxiety, personality disorder.
Respiratory:
dyspnoea, rhinitis.
Skin:
flushing, rash, pruritus, urticaria.
Other:
anaphylactic reaction
, hyper
sensitivity, injection site pain.
Interactions
None reported.
Contraindications
Contraindicated in individuals with known
hypersensitivity to the preparation; in
individuals with acute or chronic severe
renal insufficiency or renal insufficiency
due to hepatorenal syndrome; and in the
perioperative period in liver transplantation.
care considerations
• Increased risk of nephrogenic systemic
fibrosis in individuals with acute or chronic
renal failure or acute renal insufficiency,
or during the perioperative period in liver
transplantation. Renal function should
be assessed in all individuals prior to the
procedure.
• Gadodiamide may interfere with calcium
and other electrolyte measurements for up
to 24 hours.
• Closelymonitor individualfordevelopment
of anaphylactic reaction. Ensure emergency
management equipment is available and in
correct working order.
• Monitor vital signs closely following
procedure.
Patient teaching
• Advise person to report any adverse
effects.
gadopentetate
Magnevist
Pregnancy risk category B2
Use in sport: Permitted
Available forms
Single-usevial:
469mg/mL (0.5mmol/mL) in
5 mL, 10 mL, 15 mL, 20 mL, 30 mL
Prefilled syringe:
469 mg/mL in 10 mL,
15 mL, 20 mL
Indications & dosages
➤
EnhancementofCNSorwhole-bodyMRI—
Adultsandchildrenover2years:
0.1mmol/
kgbodyweight(0.2mL/kgbodyweight)by IV
bolus or infusion.
Action
Paramagnetic contrast agent used for imag
ing of intracranial and spinal lesions in
presence of abnormal blood–brain barrier
or abnormal vascularity, as well as whole-
body imaging.
Route Onset
Peak
Duration
IV
Immediate Unknown 24 hrs
Adverse reactions
CNS:
burning sensation,
coma
, convulsions,
dizziness, dysgeusia, headache,
loss of
consciousness
, paraesthesia, somnolence,
syncope, tremor.
