Diagnostic preparations 1303
Respiratory:
apnoea
,
bronchospasm
,
cough, dyspnoea,
laryngeal oedema
,
rhinitis, wheezing.
Skin:
erythema, pruritus, sweating, urticaria.
Other:
anaphylactic reaction
,
angio-
oedema
, asthenia, fatigue, hypersensitivity,
injection site pain, malaise.
Interactions
None reported.
Contraindications
Contraindicated in individuals with known
hypersensitivity to the preparation or other
gadolinium-based contrast media and in
children under 6 months of age.
care considerations
• Increased risk of nephrogenic systemic
fibrosis in individuals with acute or chronic
renal failure or acute renal insufficiency,
or during the perioperative period in liver
transplantation. Renal function should
be assessed in all individuals prior to the
procedure.
• For individuals on chronic haemodialysis,
initiate haemodialysis promptly following
administration of gadoteridol to increase
elimination.
• Closelymonitor individualfordevelopment
of anaphylactic reaction. Ensure emergency
management equipment is available and in
correct working order.
• Monitor vital signs closely following
procedure.
Patient teaching
• Advise person to report any adverse
effects.
gadoxetic acid
Primovist
Pregnancy risk category B3
Use in sport: Permitted
Available form
Prefilled syringe:
181.43mg/mL (0.25mmol/
mL) in 10 mL
Indications & dosages
➤
EnhancementofMRIoffocal liver lesions—
Adults:
0.1mL/kgbodyweight(25micromol/
kg) by IV bolus or infusion.
Action
Paramagnetic contrast agent used for imag
ing of intracranial and spinal lesions in
presence of abnormal blood–brain barrier
or abnormal vascularity, as well as whole-
body imaging.
Route Onset
Peak
Duration
IV
Immediate Unknown Unknown
Adverse reactions
CNS:
akathisia, dizziness, dysgeusia, head
ache, paraesthesia, parosmia, restlessness,
tremor, vertigo.
CV:
bundle branch block, flushing, hyper
tension, palpitations, tachycardia,
QT
prolongation
.
GI:
dry mouth, nausea, oral discomfort,
salivary hypersecretion, vomiting.
GU:
acute kidney injury
.
Musculoskeletal:
back pain, chest pain,
nephrogenic systemic fibrosis
.
Respiratory:
dyspnoea
,
respiratorydistress
.
Skin:
hyperhidrosis, pruritus, rash, urticaria.
Other:
anaphylactic reaction
,
angio-
oedema
, chills, fatigue, hypersensitivity,
injection site pain, malaise.
Interactions
Drug-drug.
Rifampicin:
Blocked hepatic
uptake of gadoxetic acid and reduced
hepatic contrast effect.
Contraindications
Contraindicated in individuals with known
hypersensitivity to the preparation.
