1304 Miscellaneous drug categories
Reactions may be
common
, uncommon,
life-threatening
, or
commonandlife-threatening.
care considerations
• Increased risk of nephrogenic systemic
fibrosis in individuals with acute or chronic
renal failure or acute renal insufficiency,
or during the perioperative period in liver
transplantation. Renal function should
be assessed in all individuals prior to the
procedure.
• For individuals on chronic haemodialysis,
initiate haemodialysis promptly following
administration of gadoxetic acid to increase
elimination.
• Closelymonitorindividualfordevelopment
of anaphylactic reaction. Ensure emergency
management equipment is available and in
correct working order.
• Monitor vital signs closely following
procedure.
Patient teaching
• Advise person to report any adverse
effects.
iodixanol
Visipaque
Pregnancy risk category B1
Use in sport: Permitted
Available forms
Bottle:
550 mg/mL in 50 mL, 100 mL;
652 mg/mL in 50 mL, 100 mL, 200 mL
Indications & dosages
➤
X-rayorCTcontrastmedium—
Adults:
Individualised according to indi
vidual factors and nature of X-ray or CT
scan.
Action
Water-solubleradiographiccontrastmedium.
Route Onset
Peak
Duration
IV
Immediate Unknown 24 hrs
Adverse reactions
CNS:
altered consciousness,
convulsion
,
dizziness, feeling hot or cold, headache,
motor dysfunction, pain, sensory disturb
ance.
CV:
arrhythmia, arterial spasm, hypertens
ion, hypotension, ischaemia,
myocardial
infarction
,
thrombosis
,
thrombophlebitis
,
STsegmentdepression
,
ventricularprema
ture beats
.
Eye:
transient blindness.
GI:
abdominal pain, nausea, vomiting.
GU:
acute renal failure
,
contrastmedium–
induced nephrotoxicity
.
Musculoskeletal:
arthralgia.
Psychiatric:
confusion.
Respiratory:
cough, dyspnoea, pulmonary
oedema.
Skin:
erythema, pruritus, rash, urticaria.
Other:
anaphylactic reaction
, fever, hyper
sensitivityreactions, iodism,malaise,pyrexia.
Interactions
Drug-drug.
Metformin/biguanides:
Potential
transient impairment of renal function with
possible lactic acidosis. Monitor closely.
Interleukin-2:
Increased risk of delayed
reactions (flu-like symptoms, skin reactions).
Monitor closely.
Beta blockers:
Atypical anaphylaxis. Monitor
closely.
Inotropic agents:
Potential myocardial
ischaemia. Monitor cardiac function closely.
General anaesthetics:
Higher incidence of
adverse effects. Monitor closely.
Contraindications
Contraindicated in individuals with known
hypersensitivity to the preparation or
a history of serious hypersensitivity to
iodixanol and in those with thyrotoxicosis.
care considerations
• Closelymonitor individualfordevelopment
of anaphylactic reaction. Ensure emergency
management equipment is available and in
correct working order.
• Monitor vital signs and renal function
closely following procedure.
• Ensure the person is well-hydrated before
and after the procedure to avoid contrast-
induced nephropathy.
