277 / 1109
Toxicity – hypofractionated and conventional scheme
•
No significant difference in toxicity
lung, cardiac, rib fractures, shoulder movement
•
40 Gy-arm: Less common normal tissue effects (START B trial)
breast oedema, breast shrinkage, telangiectasia
Haviland Lancet Oncol 2013, Haviland NEJM 2010, Whelan NEJM 2010, START B Lancet 2008,
START A Lancet Oncol 2008, Owen Lancet Oncol 2006