498 / 1109
FLAME trial
F
ocal
L
esion
A
blative
M
icroboost in prostat
E
cancer
Multicenter randomized controlled trial
Randomization:
1. Standard arm:
77 Gy in 35 fractions whole prostate (2.2 Gy per fraction)
2. Study arm:
Additional integrated boost to macroscopic tumor to 95 Gy tumor (2.7 Gy per
fraction)
Patients were blinded to the actual treatment given
Lips et al. Trials 2011