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The Norm Factor
p
p
= 0
: Volume Objective Function
1
: Linear
2
: Variance based Objective Function
Low-Objective
D
L
= D
V
for V
100%
High-Objective
D
H
= D
V
for V
0%
General Form of a
Dose Objective Function
Inverse Optimisation and Planning
1
1
i
L
i
j
N
j
p
i
j
i
L
i
i
D d
d D
N
f
i
x
x
1
1
i
H
i
j
N
j
p i
H
i
j
i
i
D d
D d
N
f
i
x
x