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Development of multi-agent chemo led to cure in lymphoma

patients

Most frequently used today are CHOP, ABVD and BEACOPP

Typical side effects include alopecia, aplasia, infection,

neuropathy, fatigue and infertility

Major long-term effects are 2

nd

neoplasia and organ failure

Prognosis of pts much worse at relapse (DLBCL, HL)

New less toxic drugs have become available and might improve

the long-term prognosis

Chemotherapy of malignant lymphoma