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Development of multi-agent chemo led to cure in lymphoma
patients
•
Most frequently used today are CHOP, ABVD and BEACOPP
•
Typical side effects include alopecia, aplasia, infection,
neuropathy, fatigue and infertility
•
Major long-term effects are 2
nd
neoplasia and organ failure
•
Prognosis of pts much worse at relapse (DLBCL, HL)
•
New less toxic drugs have become available and might improve
the long-term prognosis
Chemotherapy of malignant lymphoma