97 / 1498
FL: Reasons to initiate treatment
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B-symptoms
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Hematopoietic failure
(Hb<11g/dl, granulocytes <1.500/µl, platelets <100.000 /µl)
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Large tumor burden
(3 areas >5 cm or 1 area >7.5 cm)
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Rapid progression
(increase of tumor mass >50% within 6 months)
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Complications due to disease
(pain, infarction of spleen, hyperviscosity syndrome, etc.)
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No role for FLIPI, LDH, B2M, age, stage, or bone marrow involvement