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Localized aggressive disease: Systemic therapy is the primary treatment.

RT is used as consolidary treatment, dose 30-36 Gy after CR, 40-45 Gy if

gross residual disease

Radiation volumes may be limited to part of an organ after excellent

response to systemic treatment, which controls microscopic disease

Advanced aggressive disease: RT to initial bulk according to RICOVER

and UNFOLDER studies, extranodal disease unclear (Waldeyer’s ring was

not considered extranodal in RICOVER)

Head & neck lymphomas, aggressive