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Blocking immune

checkpoints may promote

endogenous antitumour

activity

PD1: Inhibitory receptor

on activated T-cells, B-

cells, NK and myeloid

cells. Inhibition of T-cell

activation when engaged

by ligands (PDL1/2)

PD1 expressed on T-cells

when exposed to tumour,

and associated with

exhaustion. Blocking can

restore function

Ribas A. N Engl J Med 2012;366:2517-2519.

Exhausted T-cells