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Class I PI3K

isoform

1

Expression

Ubiquitous

Ubiquitous

Leukocytes

Leukocytes

EC

50

nM

>20,000

1900

3000

8

Idelalisib is highly selective for PI3Kδ isoform

Promising activity in relapsed / refractory (R/R) indolent non-Hodgkin

lymphoma (iNHL) in a Phase I study

2

1. Lannutti BJ, et al. Blood 2011;117:591-4;

2. Flinn IW, et al. Blood 2014;123:3406-13

;