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Adverse events occurring in >12% of patients

AE, n (%)

Any grade

Grade ≥3

Diarrhoea/colitis

63 (50)

24 (19)

Cough

40 (32)

0

Nausea

39 (31)

2 (2)

Fatigue

38 (30)

2 (2)

Pyrexia

38 (30)

4 (3)

Dyspnoea

23 (18)

6 (5)

Decreased appetite

23 (18)

1 (1)

Abdominal pain

21 (17)

3 (2)

Upper respiratory infection

21 (17)

0

Vomiting

20 (16)

3 (2)

Decreased weight

19 (15)

0

Night sweats

18 (14)

0

Pneumonia

18 (14)

15 (12)

Rash

17 (14)

2 (2)

Asthenia

16 (13)

4 (3)

Headache

16 (13)

1 (1)