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Ibrutininb in Mantle cell

17.5 months estimated

median response

duration

13.9 months estimated

median progression-

free survival

115 pts with MCL

(bortezomib-naïve

n=65; bortezomib-

exposed n=50); median

age 68; median 3 (1-6)

prior therapies;

44% refractory

Wang M et al. N Engl J Med 2013; 369: 507-516.