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Interactions between the tumour microenvironment and
malignant B cells play an important role in B-cell homing,
adhesion and migration through activation of intracellular
pathways in the B cells.
1,2
BTK’s pivotal role in signalling through B-cell surface receptors
results in activation of pathways necessary for B-cell
trafficking, chemotaxis and adhesion.
3
Covalent binding in ATP pocket of BTKL….believed to disrupt
key malignant processes and:
3,4
►
Induce apoptosis; Inhibit adhesion (may lead to lymphocytosis)
1. de Gorter DJJ, et al. Immunity 2007;26:93-104.
2.
Burger JA, et al. Bloo
2. d 2009;114:3367-3375.
3.
Buggy J et al. Int Rev Immunol 2012; 31:119-132.
4.
Chavez J, et al. Core Evid
2013; 8:37-45.
Chemical structure of ibrutinib
4
Ibrutinib: Mechanism of action