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Yttrium-90 Ibritumomab tiuxetan (Zevalin
TM
)
•
Ibritumomab
–
Murine monoclonal antibody
parent of Rituximab
•
Tiuxetan
•
90Y – Beta emitter
90
Y
Chelator
Monoclonal
antibody
Conjugated to
antibody, forming strong
urea-type bond
Stable retention of
90
Y