Flipping Book - Hema

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131I Tositumomab (Anti-B1):
Mechanism Of Action
• Tositumomab
– Murine IgG2a anti-CD20 mAb
– Triggers apoptosis, via
unique epitope
• Iodine-131 radioisotope
– Beta emission
• Short pathlength “crossfire” effect
(~1 mm)
– Gamma emission
• Allows individual dosimetry
• Essential component of treatment