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131
I Tositumomab (Anti-B1):
Mechanism Of Action
•
Tositumomab
–
Murine IgG2a anti-CD20 mAb
–
Triggers apoptosis, via
unique epitope
•
Iodine-131 radioisotope
–
Beta emission
•
Short pathlength “crossfire” effect
(~1 mm)
–
Gamma emission
•
Allows individual dosimetry
•
Essential component of treatment