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Page Background

• Risk of CNS recurrence associated with skeletal involvement is a

matter of debate, with rates of 4% and 0.6% respectively for

DLCL patients with and without skeletal involvement

• In the IELSG-14 study, CNS involvement occurred in 2.5% of

patients with primary bone DLCL

• Available evidence suggests that CNS prophylaxis is superfluous

in primary bone DLCL

Therapeutic issues