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Primary CNS Lymphoma
• Primary
– Brain
– Leptomeninges
– Eye
– Spinal cord
• Metastatic
– Leptomeninges 4-11%
– Epidural 3-5%
– Brain 1%
• Mean age = 60
• Gender: men: women - 1:1
• 23% ocular involvement
• 17% positive CSF cytology
• Clinical features
– 51% behavioral/personality
– 28% hemiparesis
– 13% seizure
• DLBCL histology
– ~85% Non-GC
• Type
• Clinical Features