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PCNSL: A unique treatment challenge

Rapidly lethal if not treated or responsive

RT alone is effective

, but CRs are brief (median survival– 1 yr)

Adding CHOP or CHOD does not improve RT alone results

High-Dose Methotrexate

is the mainstay of effective treatment best for

inducing a complete response

There may be a small benefit from adding rituximab

High-dose ARA-C has also been used for consolidation and salvage

High-dose chemotherapy with autologous stem cell rescue has been

suggested as an alternative to RT consolidation for fit patients