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PCNSL: A unique treatment challenge
•
Rapidly lethal if not treated or responsive
•
RT alone is effective
, but CRs are brief (median survival– 1 yr)
•
Adding CHOP or CHOD does not improve RT alone results
•
High-Dose Methotrexate
is the mainstay of effective treatment best for
inducing a complete response
•
There may be a small benefit from adding rituximab
•
High-dose ARA-C has also been used for consolidation and salvage
•
High-dose chemotherapy with autologous stem cell rescue has been
suggested as an alternative to RT consolidation for fit patients