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The debated role of RT consolidation
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A brief (forgotten) history of WBRT alone
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The breakthrough for cure with MTX followed by WBRT
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The great concern of post-MTX
radiation-related neurotoxicity
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Efforts to match the results of combined modality with higher dose
chemotherapy alone and effective salvage
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The controversial phase III study
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High-dose chemotherapy with autologous stem cell transplantation
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An alternative combined modality with low-dose RT and rare toxicity