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PCNSL

-

Neurotoxicity

Risk Factors

Age > 60, MTX followed by full-dose whole brain RT

Clinical Features

Imaging changes evident in most patients by 6 months after radiation

Clinical changes began at a median of 1 month in one study

Four domains most sensitive to disease and treatment

Attention

Executive Functions

Memory

Psychomotor Speed

Occurs in many patients > 60 treated with MTX-WBRT (full dose)