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Multivariate analysis of prognostic factors

correlated with response to Zevalin for NHL

• Analysis of 4 clinical registrational studies

• Patients with extensive prior therapy (1-9 regimens), bulky disease,

splenomegaly

• Disease bulk (< 5 cm) correlated with overall response rate (89

patients ORR 90% (p<0.001)

• Other unfavourable characteristics (high LDH, extranodal disease,

splenomegaly, extensive prior therapy, elevated peripheral B cell

count) that might have been expected to confer a reduced probability

of response failed to do so

Czuczman et al Proc ASCO 2002