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0

10

20

30

40

50

60

70

80

90

100

Zevalin

Last

Rituximab

Last

Chemo-

therapy

Patients (%)

0

2

4

6

8

Zevalin

Last

Rituximab

Last

Chemo-

therapy

Months

Rituximab-Refractory Trial:

Patient Response to Zevalin

Overall response rate

Estimated duration of response

15%

CR

74%

6.4

32%

64%

4.4

6.5

n

=54

n

=54

n

=51

n

=17

n

=34

n

=17

P

=0.002

P

=0.002

Median TTP in responders 9.1 months (range: 3.5 to 25.9+ months)