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HL treatment changes since 1965

MOPP: Mechlorethamine, vincristine, procarbazine, prednison

ABVD: Doxorubicin, bleomycin, vinblastine, dacarbazine

ABV:

Doxorubicin, bleomycin, vinblastine

BEACOPP: Bleomycin, etoposide, doxorubicin, cyclophosphamide,

vincristine, procarbazine, prednison

Chemotherapy

Radiotherapy

Trend: ↓ dose alkylating

Trend: ↓ RT target volumes, ↓ RT dose

<1980

MOPP(like) & single agents

<1980

Classical fields

1980-1995

MOPP/ABVD; MOPPABV

1980-1995

Classical fields; IFRT

>1995

ABVD; MOPP-ABV; EBVP; BEACOPP >1995

IFRT

>2012

Brentuximab-vedotin containing regimens >2006

INRT; ISRT

Hodgson, ASH educational 2011